The technology is to make extracts precipitate as crystal at micron or sub-micron scales by removing the solvent (organic solvents in Supercritical Anti-Solvent[SAS]) with Supercritical fluid CO2 or decreasing the solvent power of solvent (Supercritical fluid CO2 in Rapid Expansion of Supercritical Solutions [RESS]). A green innovation of activators refining for biochemical or pharmaceutical industries.